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biopolymers to serve as carriers for antimicrobial and antitumoral drugs.
Table 2.2 Antitumoral nanoparticles (NPs), nanofibers and nanofilms/antimicrobial nanoparticles (NPs), nanofibers and nanofilms/tissue engineered nanofibers and nanofilms.
| Nanomaterials | Actions | References |
|---|---|---|
| Bicalutamide folate conjugated‐chitosan functionalized PLGA NPs | NPs presented potential action against prostate cancer | Dhas et al. (2015) |
| Tumor‐targeting delivery system of paclitaxel by PEGylated O‐carboxymethyl‐chitosan NPs grafted with cyclic Arg‐Gly‐Asp peptide | NPs presented potential action against Lewis lung carcinoma | Lv et al. (2012) |
| PEGylated chitosan nanocapsules conjugated to a monoclonal antibody anti‐TMEFF‐2 targeted delivery of docetaxel | Nanocapsules presented potential action against non‐small cell lung carcinoma | Torrecilla et al. (2013) |
| Doxorubicin hyaluronic acid block copolymers NPs | NPs used as a self‐targeting drug delivery in overexpressed CD44 glycoprotein cells of breast cancer | Nitta and Numata (2013) |
| Indocyanine green‐Levan NPs | Self‐assembled indocyanine green‐Levan NPs used for targeted breast cancer imaging | Kim et al. (2015) |
| Doxorubicin‐carboxymethyl xanthan gum‐capped gold NPs | NPs showed in vitro efficacy against glioblastoma cells | Alle et al. (2019) |
| Doxorubicin‐loaded alginic acid/poly[2‐(diethylamino)ethyl methacrylate] NPs | NPs exhibited greater in vivo antitumoral activity compared to free doxorubicin | Cheng et al. (2012) |
| Cationized dextran and pullulan modified with diethyl aminoethyl methacrylate (DEAEM) | Positively charged nanocomplexes with DNA and they are cytocompatible in C6, HeLa and L929 cells. Transfection efficiency of the vectors was evaluated using p53 plasmid, which demonstrated good transfection in isolated cancer cells (C6 and HeLa) | Sherly et al. (2020) |
| Alginate nanogel encapsulating Artemisia ciniformis extract | Nanogels loaded with A. ciniformis extract inhibited cell proliferation and arrested the cell cycle at the G0/G1 phase. Induction of apoptosis occurred in a time‐ and dose‐dependent manner; expression levels of pro‐apoptotic genes were up‐regulated; down‐regulation of anti‐apoptotic and metastatic genes were detected; nanogels exhibited potent anticancer activity against AGS gastric cancer cells | Rahimivand et al. (2020) |
| Bacterial cellulose + Fe3O4 NPs | Magnetic materials made from tetraaza macrocyclic Schiff base bacterial cellulose ligands with magnetite nanoparticles (Fe3O4 NPs) effectively inhibited the growth of the CT26 tumor models in BALB/c mice | Chaabane et al. (2020) |
| Clindamycin phosphate‐xanthan gum‐ZnO NPs | NPs applied as topical anti‐inflammatory drug carrier for acne treatment | Karakuş (2019) |
| Chitin | Silver NPs associated with chitin/Ag nanofibers presented strong antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, and Influenza A virus | Park and Kim (2015) |
| Polycaprolactone(PCL)/gelatin + terbinafine hydrochloride (TFH) | Nanofibers presented antifungal activity against Trichophyton mentagrophytes, Aspergillus fumigatus and Candida albicans | Paskiabi et al. (2017) |
| Chitosan + gentamicin loaded liposome | Liposome presented antibacterial activity against E. coli, P. aeruginosa and Staphylococcus aureus | Monteiro et al. (2015) |
| Chitosan (CS)/poly(vinyl alcohol) (PVA) + silver nanoparticles | CS/PVA nanofibers containing Ag NPs showed high antibacterial activity against E. coli | Nguyen et al. (2011) |
| Poly(D,L‐lactic acid‐co‐glycolic acid) (PLGA) + fusidic acid (FA) and rifampicin (RIF) nanofibers | Dual‐loaded nanofibers exhibited in vitro antimicrobial activity against two strains of methicillin‐resistant S. aureus (MRSA) and Staphylococcus epidermidis | Rho et al. (2006) |
| Zinc ions (Zn2+)‐loaded 2,2,6,6‐tetramethylpiperidine‐1‐oxyl oxidized bacterial cellulose (TOBC) nanofiber‐reinforced biomimetic calcium alginate hydrogel | Calcium alginate/TOBC biomimetic hydrogels loaded with Zn2+ exhibited good mechanical, antimicrobial, and biological properties at Zn2+ concentration of 0.0001 wt%. | Zhang et al. (2019) |
| Polyhydroxybutyrate/poly(butyleneadipate‐co‐terephthalate) (PHB/PBAT)‐based biodegradable antibacterial hydrophobic nanofibrous membranes | Nanofibrous membranes were tested against E. coli and S. aureus and presented good antimicrobial activity with 6.08 and 5.78 log reduction, respectively | Lin et al. (2017) |
| Chitosan nanofiber | Biocompatible chitosan nanofiber membranes used for bone regeneration in rabbit calvarial defects with healing effect and no evidence of inflammatory reaction | Shin et al. (2005) |
| Collagen/elastin nanofibers | Nanofibers coated with ECM proteins with good potential for wound dressing and scaffolds for tissue engineering | Rho et al. (2006) |
| Poly (L‐lactide‐co‐glycolide) (PLGA)/chitin nanofibers | Biodegradable electrospun nanofibers of PLGA and chitin presented cell adhesion and spreading for normal human keratinocytes, and were good matrices for normal human fibroblasts | Min et al. (2004) |
| Poly (L‐lactide‐co‐glycolide) (PLGA)/dextran nanofibers | Nanofibers based on blends of dextran and PLGA were tested in terms of interaction with dermal fibroblasts considering cell viability, proliferation, attachment, migration, extracellular matrix deposition, and cytoskeleton organization, and the functional gene expressions were characterized, scaffolds with good potential to enhance the healing of chronic or trauma wounds | Pan et al. (2006) |
| Poly(ε‐caprolactone) (PCL)/gelatin + metronidazole | Metronidazole was loaded in PCL/gelatine, and a sustained release was observed and significantly prevented anaerobic bacteria colonization; cytocompatibility for drug concentrations up to 30% | Xue et al. (2014) |
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