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Routes to Essential Medicines. Peter J. HarringtonЧитать онлайн книгу.

Routes to Essential Medicines - Peter J. Harrington


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      Routes to Essential Medicines

      A Workbook for Organic Synthesis

       Peter J. Harrington

       Better Pharma Processes, LLC

       Louisville, CO, USA

      This edition first published 2022

      © 2022 John Wiley & Sons, Inc.

      All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

      The right of Peter J Harrington to be identified as the author of this work has been asserted in accordance with law.

      Registered Office John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA

      Editorial Office 111 River Street, Hoboken, NJ 07030, USA

      For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

      Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats.

      Limit of Liability/Disclaimer of Warranty In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of experimental reagents, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each chemical, piece of equipment, reagent, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. While the publisher and authors have used their best efforts in preparing this work, they make no representations or warranties with respect to the accuracy or completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives, written sales materials or promotional statements for this work. The fact that an organization, website, or product is referred to in this work as a citation and/or potential source of further information does not mean that the publisher and authors endorse the information or services the organization, website, or product may provide or recommendations it may make. This work is sold with the understanding that the publisher is not engaged in rendering professional services. The advice and strategies contained herein may not be suitable for your situation. You should consult with a specialist where appropriate. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this work was written and when it is read. Neither the publisher nor authors shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.

       Library of Congress Cataloging‐in‐Publication Data applied for:

      ISBN: 9781119722861

      Cover image: [Production Editor to insert]

      Cover design by [Production Editor to insert]

       This workbook is dedicated to everyone who made it their mission in life to discover and manufacture Essential Medicines and to: Professor Louis S. Hegedus

       Who inspired this workbook project with a lesson learned at Colorado State University: An hour in the library will save you from two weeks of floundering around in the laboratory.

      About the Companion Website

       www.wiley.com/go/Harrington/routes_essential_medicine

      Introduction

      In my first Organic Chemistry class at Canisius College more than forty years ago, I recognized the power synthetic organic chemists have to create new medicines to improve human healthcare. With great power comes great responsibility. The synthetic organic chemistry community accepted this responsibility: the result is our World Health Organization (WHO) Model List of Essential Medicines.

      Routes to Essential Medicines: A Workbook for Organic Synthesis highlights the synthetic organic chemistry in the manufacturing routes of nearly three hundred medicines on the World Health Organization (WHO) Model List of Essential Medicines (20th List from March 2017). The workbook includes all the medicines on the list for which synthetic organic chemistry plays an important role in the manufacturing process.

      Routes to Essential Medicines: A Workbook for Organic Synthesis is intended for use by upper‐level undergraduate students and graduate students participating in a course in organic synthesis or medicinal chemistry. Students using this workbook will become familiar with the structures and synthetic challenges associated with nearly three hundred essential medicines and gain an appreciation for the manufacture of specialty chemical starting materials. Students who use this workbook will develop a solid foundation for their academic and postacademic research: an extensive favorites list of key journal and information sites and a personal library of reagents,


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