Poly(lactic acid). Группа авторовЧитать онлайн книгу.
at least four hydroxyl groups [27]. The PLA obtained has a higher molecular weight than a polymer prepared without the use of comonomer, but the invention has a clear limit in obtainable molecular weight. If the polyhydroxyl compound is used in large amounts, the polymer will be hydroxyl terminated and the condensation reaction cannot continue, thus yielding a low‐molecular‐weight polymer. On the other hand, if the polyhydroxyl compound is used in small amounts, the effect of the polyhydroxyl compound will diminish and the polycondensation reaction will be a blend of star‐shaped PLA and linear PLA. A hyperbranched PLA of high molecular weight was also manufactured by coupling a first prepolymer having at least three functional end groups with a second prepolymer having at least two functional end groups by a condensation reaction between the end groups in the prepolymers [28]. The improvement of the process was that the number of arms and/or molecular weight of the functionalized prepolymers could be accurately adjusted, thus affecting the properties of the resulting hyperbranched polymer in a desired way. Molecular weight in excess of 200,000 g/mol (GPC relative to PS standards in chloroform at 30°C) was obtained for the hyperbranched PLA.
Lactide has been used as a coreactant and yield enhancer in the polycondensation reaction of lactic acid [29]. M ws in the range of 65,000–83,000 g/mol were obtained in 17–42 h (GPC, 40°C, chloroform), starting from 90 wt% lactic acid, when an inorganic solid acid catalyst (aluminum silicate) was used.
Copolymers with high enough molecular weight for practical use were prepared from succinic acid and 1,4‐butanediol and minor amounts of lactic acid [30]. An increase in the reaction rate was reported when the aliphatic diol and the aliphatic dicarboxylic acid were polycondensated using a few mole percent of lactic acid and a germanium oxide catalyst.
3.2.2 Solid‐State Polycondensation
The disadvantage of the PLA prepared by direct polycondensation is often a limited molecular weight in combination with a low yield. Some progress in increasing the molecular weight of the PLA has recently been achieved, though, by sequential melt/solid polycondensation [5, 31].
In sequential melt/solid‐state polycondensation, the three first stages as described for direct polycondensation (i.e., removal of the free water content, oligomer polycondensation, and melt polycondensation) are utilized with an additional fourth stage. In the fourth stage, the melt‐polycondensated PLA is cooled below its melting temperature, often followed by particle formation as it solidifies. The solid particles are then subjected to a crystallization process, where two phases can be identified: a crystalline phase and an amorphous phase. It is believed that the reactive end groups, as well as the catalyst, are concentrated in the amorphous phase in between the crystals (Figure 3.3), thus yielding an apparent enhancement of the polycondensation rate although the polycondensation is performed in the solid state at a low temperature (i.e., below the melting temperature of the polymer). A metal catalyst can catalyze the solid‐state polycondensation in the amorphous phase, as well as the melt‐polycondensation. These catalysts can be different metals or metal salts, from metals such as Sn, Ti, and Zn.
FIGURE 3.3 Schematic description of the solid‐state polycondensation.
The rate‐determining step in solid‐state polycondensation is the mass transport of the reaction water by molecular diffusion. The removal of water can be further enhanced by carrying out the reaction under vacuum conditions in an inert atmosphere.
A process for preparing PLA by sequential melt/solid‐state polycondensation has been described [32]. The process comprises a liquid‐phase polycondensation reaction step, followed by a solidification and particle formation step of the prepolymer formed, by crystallization of the prepolymer particles, and finally a solid‐phase polymerization step. The weight‐average molecular weight of linear PLA obtained by this process was above 100,000 g/mol, which in many cases was a 10‐fold increase when compared with the prepolymer. The total process time to prepare the PLA was about 100 h, starting from 88% lactic acid. The weight‐average molecular weight was determined by GPC at 40°C in chloroform compared with polystyrene standards. A similar process for making poly(hydroxycarboxylic acid) was described where a low‐molecular‐weight polycondensate was pelletized and crystallized, and a solid‐phase polycondensation reaction step was performed by heating the pellets to a temperature not lower than the crystallization temperature [33]. According to the invention, pellets of poly(hydroxycarboxylic acid) of low molecular weight caused no blocking in the equipment, and it was possible to efficiently prepare poly(hydroxycarboxylic acid) of high molecular weight. The weight‐average molecular weight obtained by this process was in the range of 128,000–152,000 g/mol (GPC, 40°C, chloroform) requiring a minimum solid‐phase polycondensation reaction time of 40 h.
Stereoblock PLA was synthesized by solid‐state polycondensation of a 1:1 mixture of PLLA and PDLA [34]. In the first step, PLLA and PDLA having a medium molecular weight were melt polycondensated. The PLLA and PDLA were then melt blended in a 1 : 1 weight ratio to allow the formation of their stereocomplex, and the blend was subjected to solid‐state polycondensation. Some process optimization with regard to polymerization conditions was done and molecular weights exceeding 100,000 g/mol were obtained for the stereoblock PLA (GPC relative to poly(methyl methacrylate) (PMMA) standards with hexafluoroisopropanol (HFIP) as the eluent). In another study, it was found that the weight‐average molecular weight of the resultant stereoblock PLA was strongly influenced by the lactide/oligomer content in the melt blend, which is determined by the melt‐blending conditions because it is directly correlated with the crystallinity of the polycondensation products [35]. The effect of crystallization on the solid‐state polycondensation of PLLA has also been investigated [36]. The results showed that the M w of the PLA reached a maximum value when a crystallization time of 30 min (105°C) and solid‐state polycondensation of 35 h (135°C) were used.
3.2.3 Azeotropic Dehydration
In azeotropic dehydration, the same principle stages as in direct melt condensation of lactic acid are present, with the exception that the last high viscosity melt‐polycondensation stage is eliminated because the polycondensation is performed in solution. The removal of the reaction water from the reaction medium thus becomes easier and a higher PLA molecular weight is achievable. The solvent, on the other hand, has to be dried from the water produced in the reaction using a drying agent (e.g., molecular sieve). Alternatively, fresh, dry organic solvent can be added during the reaction, which is undesirable from both an environmental and an economical point of view. Another disadvantage when using organic solvents in the dehydration reaction is that the prepared polymer has to be collected from the solvent, typically by using a nonsolvent for the polymer, and dried. These steps use extra labor, are time‐consuming, and usually lower the yield of the raw material used. The boiling point of the solvent also sets a restriction on the polycondensation temperature that can be used. However, the optical purity of the PLA can be retained because of the lower temperature.
Several patent applications have been filed on the azeotropic dehydration of PLA. A process was claimed wherein the organic solvent was removed from the reaction mixture and an additional solvent, that had a water content less than the water content of the solvent removed from the reaction mixture, was added to the reaction mixture [37]. The removed solvent was dried using, for example, molecular sieves, phosphorus pentaoxide, or metal hydrides and added back to the reaction mixture. In another similar application, the drying agent used was an ion exchange resin [38]. Examples of solvents that were claimed included anisole or diphenyl ether. Azeotropic dehydration of lactic‐acid‐containing impurities (e.g., chain terminators such as methanol, ethanol, acetic acid, and pyruvic acid) in a total amount of 0.3 mol% has also been reported [39]. When the lactic acid contained 0.16 mol% methanol, a molecular weight of 50,000 g/mol (viscometry, dichloromethane, 20°C) was obtained in diphenyl ether at 130°C using tin powder as a catalyst. A methanol content