Secondary Metabolites of Medicinal Plants. Bharat SinghЧитать онлайн книгу.
and its analogue 10-hydroxycamptothecin in the tender leaves of C. acuminata saplings was studied. In screening experiments for plant growth regulators, thiourea, triacontanol, and ascorbic acid had no positive effects on the accumulation of the alkaloids. However, treatments with 40 chlormequat chloride, choline chloride, paclobutrazol, and daminozide (B9) induced camptothecin and 10-hydroxycamptothecin accumulation in both preharvest and postharvest stages. Various concentrations of growth hormones were sprayed on tender leaves of C. acuminata saplings at preharvest and postharvest stages (Liu and Adams 1998). Treatment of chlormequat chloride dramatically enhanced 10-hydroxycamptothecin production by 308% in preharvest and by 100% in postharvest. In the preharvest treatment, spraying the leaves with choline chloride resulted in 94% increase of camptothecin, and spraying with growth hormones reached 167% increase of 10-hydroxycamptothecin; treatments with choline chloride resulted in maximum increase of camptothecin and 10-hydroxycamptothecin in postharvest. Treatments with daminozide had the highest impact on camptothecin and 10-hydroxycamptothecin accumulation. The optimal concentration of growth hormones for obtaining the highest levels of camptothecin and 10-hydroxycamptothecin was determined. In most cases, the preharvest treatment was better than the postharvest one. These preliminary results suggest that the application of plant growth regulators may be a useful and feasible method to increase camptothecin and 10-hydroxycamptothecin levels in C. acuminata (Zeng et al. 2012).
References
1 Buta, J.G. and Novak, M.J. (1978). Isolation of camptothecin and 10-methoxycamptothecin from Camptotheca acuminata by gel permeation chromatography. Ind. Eng. Chem. Prod. Res. Dev. 17: 160–161.
2 Carte, B.K., Debrosse, C., Eggleston, D. et al. (1990). Isolation and characterization of a presumed biosynthetic precursor of camptothecin from extracts of Camptotheca acuminata. Tetrahedron 46: 2747–2760.
3 Chen, F. and Wang, Y.M. (2011). Effect of hydroxycamptothecin on the proliferation and apoptosis of human breast cancer cell line MCF-7. China Med. Her. 8: 17–19.
4 Chen, P., Lei, D.L., and Liu, B. (2004). Inhibitory effects of hydroxycamptothecin on cell activity and telomerase activity in squamous cell carcinoma of tongue. China J. Mod. Med. 14: 72–74.
5 Chen, P., Liu, B., and Hu, M. (2013). The effect of hydroxycamptothecin and pingyangmycin on human squamous cell carcinoma of the tongue. Oncol. Lett. 5: 947–952.
6 Chen, M., Li, Y., Xu, D. et al. (2017). One-step targeted accumulation and detection of camptothecin analogues from fruits of Camptotheca acuminata Decne using bilayer solid-phase extraction coupled with ultra-high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 1524: 37–48.
7 Guo, Q. and Yuan, Q. (2016). A novel 10-hydroxycamptothecin-glucoside from the fruit of Camptotheca acuminata. Nat. Prod. Res. 30: 1053–1059.
8 Hatano, T., Ikegami, Y., Shingu, T., and Okuda, T. (1988). Camptothins A and B: new dimeric hydrolyzable tannins from Camptotheca acuminate Decne. Chem. Pharm. Bull. 36: 2017–2022.
9 He, F., Zeng, Y.Y., and Wang, T. (2006). Change of mitochondria during apoptosis of HL-60 cells induced by camptothecine. Chin. J. Cell. Mol. Immunol. 22: 144–147.
10 van Hengel, A.J., Harkes, M.P., Wichers, H.J. et al. (1992). Characterization of callus formation and camptothecin production by cell lines of Camptotheca acuminata. Plant Cell Tissue Organ Cult. 28: 11–18.
11 Hisang, Y.H., Herizberg, R., Hecht, S., and Liu, L.F. (1985). Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem. 260: 14873–14878.
12 Hsu, J.S., Chao, T.Y., Lin, L.T., and Hsu, C.F. (1977). Chemical constituents of the anticancer plant Camptotheca acuminata Decne. II. Chemical constituents of the fruits of Camptotheca acuminata Decne. Huaxue Xuebao 35: 193–200.
13 Jain, A.K. and Nessler, C.L. (1996). Clonal propagation of Camptotheca acuminata through shoot bud culture. Plant Cell Tissue Organ Cult. 44: 229–233.
14 Lan, H.H., Shi, J.Q., and Chen, F.M. (2010). Apoptosis induced in bladder cancer cell line T24 by hydroxycamptothecine. J. Contemp. Urol. Reprod. Oncol. 2: 94–97.
15 Lansiaux, A., Facompré, M., Wattez, N. et al. (2001). Apoptosis induced by the homocamptothecin anticancer drug BN80915 in HL-60 cells. Mol. Pharmacol. 60: 450–461.
16 Li, Z. and Liu, Z. (2005). Plant regeneration from leaf petioles in Camptotheca acuminata. In Vitro Cell. Dev. Biol. Plant 41: 262–265.
17 Li, S. and Wang, P. (2014). Phytochemistry of Camptotheca Decaisne. Pharm. Crops 5 (Suppl 2: M9): 163–172.
18 Li, S., Yi, Y., Wang, Y. et al. (2002a). Camptothecin accumulation and variations in Camptotheca. Planta Med. 68: 1010–1016.
19 Li, W.W., Yan, Z.W., and Shi, K. (2002b). Experimental study on the viricidal effect of rough extracts of camptothecine fruit on herpes simplex virus-2 in vitro. Bull. Human Med. Univ. 27: 123–124.
20 Li, G.Q., Chen, N.H., Zhang, Y.B. et al. (2017). Six new pentacyclic triterpenoids from the fruit of Camptotheca acuminata. Chem. Biodivers. 14: e1600180.
21 Li, S., He, H., Xi, Y., and Li, L. (2018). Chemical constituents and pharmacological effects of the fruits of Camptotheca acuminata: a review of its phytochemistry. Asian J. Trad. Med. 13: 40–48.
22 Lin, L.Z. and Cordell, G.A. (1989). Quinoline alkaloids from Camptotheca acuminata. Phytochemistry 28: 1295–1297.
23 Lin, L.Z. and Cordell, G.A. (1990). 9-O-Methylangustoline from Camptotheca acuminata. Phytochemistry 29: 2744–2746.
24 Lin, L.T., Sung, C.C., and Hsu, J.S. (1978). Chemical constituents of the anticancer plant Camptotheca acuminata Decne. V. Other constituents of its fruits. Huaxue Tongbao 6: 327–328.
25 Lin, L.Z., Song, C.Q., and Xu, R.S. (1979a). Chemical constituents of the anticancer plant Camptotheca acuminata Decne. III. Ellagic acids from the fruits of Camptotheca acuminata Decne. Huaxue Xuebao 37: 207–214.
26 Lin, L.Z., Sung, C.C., and Hsu, R.S. (1979b). A new anticancer alkaloid 11-hydroxycamptothecin. Kexue Tongbao 24: 478–479.
27 Lin, L.Z., Song, C.Q., and Xu, R.S. (1982). Chemical constituents of the anticancer plant Camptotheca acuminata Decne. IV. Isolation and identification of 11-hydroxycamptothecin and other four compounds. Huaxue Xuebao 40: 85–89.
28 Lin, L.Z., Shen, J.H., He, X., and Zhang, W.Y. (1988a). Indole alkaloids from Camptotheca acuminata. Huaxue Xuebao 46: 1207–1211.
29 Lin, L.Z., Zhang, J.S., Shen, J.H. et al. (1988b). A new alkaloid – 18-hydroxycamptothecin. Yaoxue Xuebao 23: 186–188.
30 Lin, L.Z., Shen, J.H., Zhou, T. et al. (1989). New alkaloid 10-hydroxydeoxycamptothecin. Huaxue Xuebao 47: 506–508.
31 Lin, J., Wang, R.H., and Chen, H. (2013). The apoptotic activity of hydroxycamptothecin against human gastric carcinoma and its mechanism of action. Chin. J. Postgrad. Med. 36: 15–17.
32 Lin, C.S., Chen, P.C., Wang, C.K. et al. (2014). Antitumor effects and biological mechanism of action of the aqueous extract of the Camptotheca acuminata fruit in human endometrial carcinoma cells. Evid. Based Complement. Alternat. Med. 2014: 1–10.
33 Liu, Z. and Adams, J. (1998). Seed source variation in camptothecin concentrations of nursery-grown Camptotheca acuminata seedlings. New Forest. 16: 167–175.
34 Liu, W. and Reinscheid, U.M. (2004). Camptothecin-resistant fungal endophytes of Camptotheca acuminata. Mycol. Prog. 3: 189–192.
35 Liu, Z., Carpenter, S.B., Bourgeois, W.J. et al. (1998). Variations in the secondary metabolite camptothecin in relation to tissue age and season in Camptotheca acuminata. Tree Physiol. 18: 265–270.
36 Lopez-Mayer, M., Nessler, C.L., and McNight, C.D. (1997). Sites of accumulation of the antitumor alkaloid camptothecin in Camptotheca acuminata. Planta Med. 60: 558–560.
37 Lorence, A. and Nessler, C.L. (2004). Camptothecin, over four decades of surprising findings. Phytochemistry 65: 2735–2749.
38 Lorence, A.,