Secondary Metabolites of Medicinal Plants. Bharat SinghЧитать онлайн книгу.
Time course of cannabinoid accumulation and chemotype development during the growth of Cannabis sativa L. Euphytica 160: 231–240.
40 Pate, D.W. (1983). Possible role of ultraviolet radiation in evolution of Cannabis chemotypes. Econ. Bot. 37: 396–405.
41 Pisani, A., Fezza, F., Galati, S. et al. (2005). High endogenous cannabinoid levels in the cerebrospinal fluid of untreated Parkinson's disease patients. Ann. Neurol. 57: 777–779.
42 Pisani, V., Moschella, V., Bari, M. et al. (2010). Dynamic changes of anandamide in the cerebrospinal fluid of Parkinson's disease patients. Mov. Disord. 25: 920–924.
43 Pisani, V., Madeo, G., Tassone, A. et al. (2011). Homeostatic changes of the endocannabinoid system in Parkinson's disease. Mov. Disord. 26: 216–222.
44 Radwan, M.M., Ross, S., Slade, D. et al. (2008). Isolation and characterization of new Cannabis constituents from a high potency variety. Planta Med. 74: 267–272.
45 Radwan, M.M., Elsohly, M.A., Slade, D. et al. (2009). Biologically active cannabinoids from high-potency Cannabis sativa. J. Nat. Prod. 72: 906–911.
46 Radwan, M.M., ElSohly, M.A., El-Alfy, A.T. et al. (2015). Isolation and pharmacological evaluation of minor cannabinoids from high-potency Cannabis sativa. J. Nat. Prod. 78: 1271–1276.
47 Raharjo, T.J., Eucharia, O., Chang, W.-T., and Verpoorte, R. (2006). Callus induction and phytochemical characterization of Cannabis sativa cell suspension cultures. Indones. J. Chem. 6: 70–74.
48 Ross, S.A. and ElSohly, M.A. (1995). Constituents of Cannabis sativa L. XXVIII. A review of the natural constituents: 1980–1994. Zagazig J. Pharm. Sci 4: 1–10.
49 Ross, S.A., ElSohly, M.A., Sultana, G.N.N. et al. (2005). Flavonoid glycosides and cannabinoids from the pollen of Cannabis sativa L. Phytochem. Anal. 16: 45–48.
50 Sato, F. and Kumagai, H. (2013). Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research. Proc. Jpn. Acad., B, Phys. Biol. Sci. 89: 165–182.
51 Shoyama, Y., Fujita, T., Yamauchi, T., and Nishioka, I. (1968). Cannabichromenic acid, a genuine substance of cannabichromene. Chem. Pharm. Bull. 16: 1157–1158.
52 Srivastava, N.K. and Srivastava, A.K. (2010). Influence of some heavy metals on growth, alkaloid content and composition in Catharanthus roseus L. Indian J. Pharm. Sci. 72: 775–778.
53 Styrczewska, M., Kulma, A., Ratajczak, K. et al. (2012). Cannabinoid-like anti-inflammatory compounds from flax fiber. Cell. Mol. Biol. Lett. 17: 479–499.
54 Tabrez, S., Jabir, N.R., Shakil, S. et al. (2012). A synopsis on the role of tyrosine hydroxylase in Parkinson's disease. CNS Neurol. Disord. Drug Targets 11: 395–409.
55 Takeda, S., Okajima, S., Miyoshi, H. et al. (2012). Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration. Toxicol. Lett. 214: 314–319.
56 Turner, C.E., Mole, M.L., Hanus, L., and ElSohly, H.N. (1981). Constituents of Cannabis sativa. XIX. Isolation and structure elucidation of cannabiglendol, a novel cannabinoid from an Indian variant. J. Nat. Prod. 44: 27–33.
57 Wahby, I., Caba, J.M., and Ligero, F. (2013). Agrobacterium infection of hemp (Cannabis sativa L.): establishment of hairy root cultures. J. Plant Interact. 8: 312–320.
58 Wang, R., He, L.-S., Xia, B. et al. (2009). A micropropagation system for cloning of hemp (Cannabis sativa l.) by shoot tip culture. Pak. J. Bot. 41: 603–608.
59 Whiting, P.F., Wolf, R.F., Deshpande, S. et al. (2015). Cannabinoids for medical use: a systematic review and meta-analysis. JAMA 313: 2456–2473.
60 Yamaguchi, S., Shouji, N., and Kuroda, K. (1995). A new approach to d,l-cannabichromene. Bull. Chem. Soc. Jpn. 68: 305–308.
61 Zhang, W.J. and Björn, L.O. (2009). The effect of ultraviolet radiation on the accumulation of medicinal compounds in plants. Fitoterapia 80: 207–218.
2.20 Capsicum Species
2.20.1 Ethnopharmacological Properties and Phytochemistry
Capsicum annuum L. var. Bronowicka Ostra (Fam. – Solanaceae) has been studied with regard to the content of flavonoids and other phenolics. Capsaicin, an alkaloid, is used mainly as a pungent substance in formulated foods, obtained from fruits of Capsicum species. It is also used in pharmaceutical preparations as a digestive stimulant and for treatment of rheumatic disorders and has analgesic effects (Sooch et al. 1977; Deal et al. 1991; Menéndez et al. 2004). C. annuum is cultivated in tropical and subtropical geographical regions and exhibits a range of biological activities including antimicrobial, antiviral, anti-inflammatory, antioxidant, and anticancer (Ludy et al. 2012; Khan et al. 2014; Kim et al. 2014). Capsaicin, capsanthin, capsanthin 3′-ester, capsanthindiester, capsorubin, capsorubin diester, capsanthin 3,6-epoxide, and β-carotene separated from C. annuum exhibited Barr virus early antigen activation stimulated by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (Maoka et al. 2001; Han et al. 2002). The capsaicin cream has been used for the treatment of acute lipodermatosclerosis and acute lobular panniculitis in pregnant women (Yosipovitch et al. 2005). It has been reported that the capsaicin desensitized nasal mucosa and decreased nasal allergy problems (Stjärne et al. 1998; Fathima 2015). The capsanthin, quercetin, luteolin, and β-carotene from C. annuum showed antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) model (Sun et al. 2007; Shotorbani et al. 2013). The content in β-carotenes, vitamin C, lycopene, and total phenols from bell pepper (C. annuum) showed antioxidant activity (Chávez-Mendoza et al. 2015). The total carotenoids, β-carotene, α-carotene, gallic acid and chlorogenic acid, quercetin D-glucoside, quercetin, kaempferol isolated from C. annuum also showed antioxidant activity against DPPH models (Hallmann and Rembialkowska 2012).
The trans-p-ferulylalcohol-4-O-(6-(2-methyl-3-hydroxypropionyl)-glucopyranoside and luteolin-7-O-(2-apiofuranosyl-4-glucopyranosyl-6-malonyl)-glucopyranoside were isolated from C. annuum. Additionally compounds such as trans-p-feruloyl-β-D-glucopyranoside, trans-p-sinapoyl-β-D-glucopyranoside, quercetin 3-O-α-L-rhamnopyranoside-7-O-β-D-glucopyranoside, luteolin 6-C-β-D-glucopyranoside-8-C-α-L-arabinopyranoside, apigenin 6-C-β-D-glucopyranoside-8-C-α-L-arabinopyranoside, and luteolin 7-O-[2-(β-D-apiofuranosyl)-β-D-glucopyranoside] were found for the first time in pepper fruit (C. annuum L.) (Materska et al. 2003). Hydroxycinnamic derivatives, O-glycosides of quercetin, luteolin, homodihydrocapsaicin, homocapsaicin, and chrysoeriol have been isolated from the C. annuum (Rowland et al. 1983; Thomas et al. 1998; Marin et al. 2004). In the latter stages of development, capsaicin, dihydrocapsaicin, kaempferol glycosides, quercetin, luteolin, and capsaicinoids were increased in C. annuum (Hasler 1998; Hayman and Kam 2008; Jang et al. 2015). The flavonoids as N-caffeoylputrescine, 5-O-caffeoylquinic acid, 5-O-caffeoylquinic acid methyl ester, 5-O-caffeoylquinic acid butyl ester, delphinidin-3-[4-trans-coumaroyl-L-rhamnosyl(1→6)glucopyranoside]-5-O-glucopyranoside, luteolin-7-O-glucopyranoside, luteolin-7-O-apiofuranosyl(1→2)glucopyranoside, apigenin-7-O-apiofuranosyl(1→2)glucopyranoside, and apigenin-7-O-glucopyranoside were isolated from C. annuum (Kim et al. 2014). The zeaxanthin monoester, capsanthin monoester, β-cryptoxanthin, β-carotene, zeaxanthin, capsanthin, and capsorubin and capsorubin monoester were separated from esterified pigment fraction of C. annuum (Hornero-Méndez and Mínguez-Mosquera 2000).
The trans-p-feruloyl-β-D-glucopyranoside, trans-p-sinapoyl-β-D-glucopyranoside, quercetin 3-O-α-L-rhamnopyranoside-7-O-β-D-glucopyranoside, trans-p-ferulylalcohol-4-O-[6-(2-methyl-3-hydroxypropionyl)] glucopyranoside, luteolin 6-C-β-D-glucopyranoside-8-C-α-L-arabinopyranoside, apigenin 6-C-β-D-glucopyranoside-8-C-α-L-arabinopyranoside, lutoeolin 7-O-[2-(β-D-apiofuranosyl)-β-D-glucopyranoside], quercetin 3-O-α-L-rhamnopyranoside, and luteolin