Long before the action of vegetable and mineral substances on human beings and animals was known, it is probable that poisonous bodies in some form were used by primitive man.

When injured in battle by perhaps a flint arrow-head, or stone axe, he sought for something to revenge himself on his enemy. In his search after curative remedies he also found noxious ones, which produced unpleasant effects when applied to the point of a weapon destined to enter the internal economy of an opponent.

He doubtless also became aware that the spear-points and arrow-heads on which the blood of former victims had dried, caused wounds that rapidly proved fatal, owing to the action of what we now call septic poisons. This probably led to experiments with the juices of plants, until something of a more deadly character was discovered.

This was the very earliest age of poisoning, when pharmacy was employed for vicious or revengeful purposes.

Thus we find that almost every savage nation and people has its own peculiar poison. In Africa the seeds of Strophanthus hispidus, or kombé, a most virulent poison, are used for this purpose; while explorers tell us that the ancient pigmy race of Central Africa employ a species of red ant crushed to a paste, to tip their arrows and spears. The South American Indians poison their arrow-heads with curare or ourari, produced from a species of strychnos and other plants, while the Malays and hill tribes of India use aconite, and other poisonous juices and extracts. The Antiaris toxicaria is also used as an arrow poison by the Malays.

The bushmen of the South African district "Kalahari," use the juice of the leaf beetle "diamphidia" and its larva for poisoning their arrow-heads. Lewin, who calls the beetle Diamphidia simplex, found in its body, besides inert fatty acids, a toxalbumin which causes paralysis, and finally death. According to Boehm, the poison from the larva also belongs to the toxalbumins, and Starke states, that it causes the dissolution of the colouring matter of the blood and produces inflammation.

A halo of mystery, sometimes intermixed with romance, has hung about the dread word poison from very early times. In the dark days of mythology, allusions to mysterious poisons were made in legend and saga. Thus a country in the Far North was supposed to be ruled and dominated by sorcerers and kindred beings, all of whom were said to be children of the Sun. Here dwelt Æëtes, Perses, Hecate, Medea, and Circe. Hecate was the daughter of Perses and married to Æëtes, and their daughters were Medea and Circe. Æëtes and Perses were said to be brothers, and their country was afterwards supposed to be Colchis. To Hecate is ascribed the foundation of sorcery and the discovery of poisonous herbs. Her knowledge of magic and spells was supposed to be unequalled. She transmitted her power to Medea, whose wonderful exploits have been frequently described and depicted, and who by her magic arts subdued the dragon that guarded the golden fleece, and assisted Jason to perform his famous deeds. Hecate's garden is described by the poets as being enclosed in lofty walls with thrice-folding doors of ebony, which were guarded by terrible forms, and only those who bore the leavened rod of expiation and the concealed conciliatory offering could enter. Towering above was the temple of the dread sorceress, where the ghastly sacrifices were offered and all kinds of horrible spells worked.

Medea was also learned in sorcery and an accomplished magician. It is related that, after her adventures with Jason, she returned with him to Thessaly. On their arrival they found Æson, the father of Jason, and Pelias, his uncle, who had usurped the throne, both old and decrepit. Medea was requested to exert her magical powers to make the old man young again, an operation she is said to have speedily performed by infusing the juice of certain potent plants into his veins.

Some years after, Medea deserted Jason and fled to Athens, and shortly afterwards married Ægeus, king of that city. Ægeus had a son by a former wife, named Theseus, who had been brought up in exile. At length he resolved to return and claim his parentage, but Medea hearing of this, and for some reason greatly resenting it, put a poisoned goblet into the hands of Ægeus at an entertainment he gave to Theseus, with the intent that he should hand

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