Vaccines For Dummies. Sharon PerkinsЧитать онлайн книгу.
new invading bacteria can make you sick. Antibiotics can work against these worrisome bacteria, but antibiotics don’t work as quickly as vaccines. Vaccines prevent you from ever getting sick, while antibiotics only reduce the symptoms once you do get sick.
Other types of pathogens include the following:
Parasites: These can be single-celled like malaria, which is a lot larger and more complicated than bacteria are. Parasites can also include worms that infect you or even tiny insects like bed bugs or scabies. We haven’t been successful at making vaccines for many of these but are now having some success with making vaccines for malaria.
Fungi: These are effectively the mini cousins of mushrooms. They include molds and yeasts. Infections may be from the environment, say from a dust storm in Arizona that can spread Valley Fever, a fungal infection, from the sand and dust. There haven’t been any approved fungal vaccines.
Prions: Like viruses, prions also aren’t really alive, and they’re even smaller. They’re just crumped proteins that can cause other proteins of the same type to crumple up in the same way. This type of infection causes Mad Cow Disease and a few other diseases, but they’re incredibly rare. We don’t yet have any vaccines for prion diseases in humans (but there is some promising work for animal diseases).
Vaccines for viruses and bacteria can include many different types (see Chapter 5 for details):
The oldest type is a similar but alive (or replicating) bacteria or virus that shows our immune system what the danger is without causing us any harm.
Another tried-and-true method is to take killed, whole bacteria or viruses. These won’t be able to infect us but will show our immune system what to watch for.
Other vaccines use small proteins or sugars, found on the outside of bacteria or viruses, that can be used to recognize pathogens.IS THIS INGREDIENT SAFE?Vaccines go through rigorous multi-stage testing to ensure they prevent disease and are safe without worrisome side effects. Once vaccines are approved, they continue to be watched for any signs of any problems. Chapter 5 looks more closely at the vaccine testing and manufacturing processes.The ingredients in vaccines are carefully monitored to ensure they don’t have worrisome side effects. The ingredients are clearly listed in the insert that comes with the vaccine. If you ever have any questions about any ingredients and whether you might be allergic to one, you can discuss this with your doctor or healthcare provider.After vaccines are approved by government agencies, including the Food and Drug Administration (FDA) in the United States, they are still monitored for any signs of problems. Anyone who is vaccinated in the United States can report any side effects to a national database that watches for and tracks patterns and serious events.The manufacturing of vaccines is also watched closely. There are ongoing inspections and monitoring of vaccine production facilities by the FDA in the United States and by other independent government organizations in other countries. Around the world, the World Health Organization (WHO) also assesses factories before they begin production for quality, safety, and efficacy. Only factories that are continually inspected and approved for production can make the vaccines.Once vaccines are produced, they undergo testing again. Vaccines are made in batches called lots. Samples from every single lot must be tested to ensure they have the pure, potent, and safe ingredients they are intended to have. No vaccine lot can be distributed until it is released by the FDA. Other countries have similar regulations. If a problem was found in a vaccine from one lot, the entire lot can be recalled.Once vaccines are released, they have to be packaged and stored in certain conditions to keep the vaccine from deteriorating. Many vaccines require what is called cold chain, meaning they have to be kept within a very specific range of cold temperatures all the way from factory to delivery for vaccination. That way, you can feel assured that the vaccine you receive is still potent when you receive it.
Some vaccines are made against the toxins that bacteria release to make us sick. The vaccine includes something similar and benign, called toxoids, which don’t make us sick, in order to teach our bodies to recognize toxins.
Two new types of vaccines have been used so far for viruses — viral vector vaccines and vaccines made from genetic material, like mRNA. These vaccines carry the genetic instructions into our cells in order to build a protein that our immune systems can use to recognize a pathogen.
Studying COVID-19 Vaccine Development
Infectious diseases have not been completely tamed. COVID-19 reminds us there are many viruses and bacteria out there that we’ve never dealt with before. It goes without saying that COVID-19 changed the world abruptly for us all. In the first full year of the pandemic (2020), it led to at least 350,000 deaths in the United States and at least 1.8 million deaths reported worldwide. Vaccines have been an important part of the solution.
No vaccines have been watched as closely as the COVID-19 vaccines as they passed through phase I, then II, then III, and onto use in the general population. The world watched as controlled trials studied the use of the vaccines versus a placebo. These trials — as well as post-rollout monitoring — looked closely for any side effects.
As we discuss in more detail in Chapter 3, many different types of vaccine methods are used today. A lot of advances in vaccine science led to the COVID-19 vaccines. The first vaccines came from science that was only a couple of decades old. The COVID-19 vaccines currently in use are messenger RNA (mRNA) or viral vector vaccines.
Vaccines were also shown to provide better protection than natural infection, especially when facing new variants of COVID-19. As COVID-19 has spread around the globe, it has collected many new mutations creating new variants, so your immune system may not recognize new variants after getting sick with a prior one. It may become necessary to have booster COVID-19 vaccinations to remain immune, just like you need to remain protected against the flu.
WHY LAST YEAR’S FLU VACCINE WON’T WORK THIS YEAR
Most vaccines work well year after year. Some, particularly for influenza, need an update. That’s because some pathogens change their looks. It’s the pathogen equivalent of a wig or a fake moustache that fools our immune systems. What the pathogen looked like last year may not be what it looks like this year, at least to our immune systems.
Pathogens may change their looks by collecting mutations that each make small changes generation after generation. Over time, in a pathogen’s family tree, the great-grandparents may look just a bit different than future generations. There may be different proteins (or sugars) on their surfaces, making them unrecognizable.
The flu does even more to dodge your immune system’s attention. Mutations build up as the flu copies itself again and again. But it does something more. It also mixes and matches the proteins on the outside. It takes a fake moustache and a hat one year, a wig and a mask another year. This means a vaccine that works this year may not work next year. Some types may persist for a few years. Others need to be updated. As we discuss in Chapter 6, a lot of thought goes into the flu vaccine each year, trying to guess six months ahead which fake moustaches and wigs will be en vogue for the flu this year. The vaccine is updated every year in both the Northern and Southern hemispheres in time to vaccinate everyone who wants it in preparation for the wintertime flu season.
Understanding the Importance of Vaccine Schedules
Unfortunately, vaccines don’t always fall into the “one and done” category. In many cases, a series of vaccines, given on a specific schedule, are necessary to provide you or your children with protection against diseases. While no one wants to get an injection more than once, skipping doses or spreading them out can decrease