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Introduction to Nanoscience and Nanotechnology. Chris BinnsЧитать онлайн книгу.

Introduction to Nanoscience and Nanotechnology - Chris Binns


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6, which focuses on single nanoparticle devices. These give about the same level of miniaturization, but the nanoscale interconnections present the same problems.

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      Source: Reproduced with the permission of Dr. Mark Everard from [5].

      No one can fail to be impressed by the huge increases in performance, and density of components/memory elements in devices made by the electronics and magnetic recording industries in the last few decades. The above example illustrates, however, that there is still a long way to go, nicely reinforcing a lecture on nanotechnology given by the visionary Nobel Laureate Richard Feynman in 1959 entitled There's Plenty of Room at the Bottom. It is remarkable to note that this vision of nanotechnology was expounded over 60 years ago.

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      Source: Reproduced with permission from Llamosa et al. [6], Reproduced with permission from Krishnan et al. [7].

      Combining the abilities of the synthesis method, Figure I.5c shows a dumbbell nanoparticle with an iron core coated with an intermediate shell of another metal and finally with a gold shell. In addition, a protein has been attached that is a piece of antibody, known as a nanobody (see Chapter 8, Section 8.1.7), which is able to locate and attach to specific cells in the body, in particular, cancer cells. Once attached to a cancer cell, the nanoparticles can perform a range of therapeutic and diagnostic functions (this combination of therapy and diagnosis is often referred to as “theranostics”). The magnetic core can be heated by applying an oscillating magnetic field from outside the body to which tissue is transparent, thus, heat is generated only at the cellular level of the cancer. Gentle heating to just a few degrees above core body temperature causes the cell to shut down and die in an orderly process known as apoptosis.

      This method, referred to magnetic nanoparticle hyperthermia and described in Chapter 8, Section 8.2 is potentially a symptom‐free and generic treatment for cancer and is waiting for designed nanoparticles such as those shown in Figure I.5c. Hyperthermia can also be induced by near infra‐red light, to which tissue is relatively transparent, interacting with the gold shell. The magnetic core can be used to provide high‐resolution images of the tumor by magnetic resonance imaging (MRI) or a new method known as magnetic particle imaging (MPI). As well as heating, the gold shell acts as a powerful X‐ray absorber to provide images of the tumor using computerized tomography (CT). The dumbbell shape of the nanoparticle also makes it possible to remotely measure the temperature at the site so that the hyperthermia can be accurately controlled. Finally, the intermediate shell can be used to introduce additional functionality, for example, it could be a radionuclide for alternative imaging methods. Thus, this type of nanoparticle can act as a nanoscale treatment centre that can provide a range of therapies and diagnoses with the most appropriate set chosen for the type of cancer. This is a highly sophisticated example of evolutionary nanotechnology.

      Finally, the most far‐reaching version of nanotechnology, described as Radical Nanotechnology by Richard Jones, is the construction of machines whose mechanical components are the size of molecules. The field has bifurcated into two distinct branches, that of molecular manufacturing in which macroscopic structures and devices are built by assembling their constituent atoms, and nanorobots or nanobots, which are invisibly small mobile machines. Molecular manufacturing was originally proposed by the Nobel laureate, Richard Feynman in his famous lecture in 1959, and was subsequently advocated with much enthusiasm by Eric Drexler [8]. In 1990, the IBM research laboratories in Zurich demonstrated that they could move and position individual atoms using a scanning tunneling microscope (STM – see Chapter 5, Section 5.4.2) lending support to the idea that molecular manufacturing may, at least in principle, be possible. The problems and the emergence of some enabling


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